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KMID : 1094020150320050404
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Journal of Veterinary Clinics
2015 Volume.32 No. 5 p.404 ~ p.409
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Evaluation for Biocompatibility of Gentamicin-collagen Sponge on the Experimental Animal Wound Model
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Yun Sun-Ho
Park Ji-Hee
Jang Kwang-Ho
Kwon Young-Sam
Park Jeong-kyu
Kim Man-Seop
Kim Dal-won
Ku Sae-Kwang
Song Moon-Yong
Kang Gyoo-Il
Hwang Won-Koo
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Abstract
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The objective of this study was to compare the biocompatibility for local irritation and bioavailability of GentacolTM and CollatampTM, after single intramuscular loading in rats. Sixty-six male Sprague-Dawley rats were divided into 4 groups; (1) any test materials were not applied into the quadriceps muscles (control group, N = 6), (2) Gentamicin was injected into the quadriceps muscles (Gentamicin group, N = 6), (3) Collatamp was applied into the quadriceps muscles (Collatamp group, N = 27), and (4) Gentacol was applied into the quadriceps muscles (Gentacol group, N = 27). The concentration of gentamicin in muscles was gradually decreased with time after loaded in the both GentacolTM and CollatampTM loaded regions. No detectable gentamicin was observed in the plasma of GentacolTM and CollatampTM loaded rats. Histologically, moderate to severe inflammatory cell infiltrations including PMN, lymphoid cells and macrophages were observed with slight to moderate edematous changes of muscle fibers after intramuscular injection of gentamicin. However, these histopathological changes of gentamicin injection induced local irritations were dramatically decreases after intramuscular loading of CollatampTM and GentacolTM. These results suggest GentacolTM may show favorable local bioavailability and induce only slight local irritations as comparable as CollatampTM without systemic exposures in the condition of this experiment.
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KEYWORD
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Biocompatibility, gentamicin, collagen sponge
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